A simple formula useful for positional cloning.
نویسندگان
چکیده
We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.
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عنوان ژورنال:
- Genetics
دوره 160 1 شماره
صفحات -
تاریخ انتشار 2002